Use and effectiveness of rituximab in children and young people with juvenile idiopathic arthritis in a cohort study in the United Kingdom.
Identifieur interne : 000653 ( Main/Exploration ); précédent : 000652; suivant : 000654Use and effectiveness of rituximab in children and young people with juvenile idiopathic arthritis in a cohort study in the United Kingdom.
Auteurs : Lianne Kearsley-Fleet [Royaume-Uni] ; Sunil Sampath [Royaume-Uni] ; Liza J. Mccann [Royaume-Uni] ; Eileen Baildam [Royaume-Uni] ; Michael W. Beresford [Royaume-Uni] ; Rebecca Davies [Royaume-Uni] ; Diederik De Cock [Royaume-Uni] ; Helen E. Foster [Royaume-Uni] ; Taunton R. Southwood [Royaume-Uni] ; Wendy Thomson [Royaume-Uni] ; Kimme L. Hyrich [Royaume-Uni]Source :
- Rheumatology (Oxford, England) [ 1462-0332 ] ; 2019.
Descripteurs français
- KwdFr :
- Adolescent, Antirhumatismaux (effets indésirables), Antirhumatismaux (usage thérapeutique), Arthrite juvénile (traitement médicamenteux), Association de médicaments, Calendrier d'administration des médicaments, Enfant, Enregistrements, Femelle, Humains, Indice de gravité médicale, Infections opportunistes (), Mâle, Produits biologiques (effets indésirables), Produits biologiques (usage thérapeutique), Rituximab (effets indésirables), Rituximab (usage thérapeutique), Résultat thérapeutique, Études de cohortes, Études de suivi.
- MESH :
- effets indésirables : Antirhumatismaux, Produits biologiques, Rituximab.
- traitement médicamenteux : Arthrite juvénile.
- usage thérapeutique : Antirhumatismaux, Produits biologiques, Rituximab.
- Adolescent, Association de médicaments, Calendrier d'administration des médicaments, Enfant, Enregistrements, Femelle, Humains, Indice de gravité médicale, Infections opportunistes, Mâle, Résultat thérapeutique, Études de cohortes, Études de suivi.
English descriptors
- KwdEn :
- Adolescent, Antirheumatic Agents (adverse effects), Antirheumatic Agents (therapeutic use), Arthritis, Juvenile (drug therapy), Biological Products (adverse effects), Biological Products (therapeutic use), Child, Cohort Studies, Drug Administration Schedule, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Injection Site Reaction (etiology), Male, Opportunistic Infections (chemically induced), Registries, Rituximab (adverse effects), Rituximab (therapeutic use), Severity of Illness Index, Treatment Outcome.
- MESH :
- chemical , adverse effects : Antirheumatic Agents, Biological Products, Rituximab.
- chemical , therapeutic use : Antirheumatic Agents, Biological Products, Rituximab.
- chemically induced : Opportunistic Infections.
- drug therapy : Arthritis, Juvenile.
- etiology : Injection Site Reaction.
- Adolescent, Child, Cohort Studies, Drug Administration Schedule, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Registries, Severity of Illness Index, Treatment Outcome.
Abstract
Rituximab (RTX) may be a treatment option for children and young people with JIA, although it is not licensed for this indication. The aim of this study was to describe RTX use and outcomes among children with JIA.
DOI: 10.1093/rheumatology/key306
PubMed: 30358861
Affiliations:
- Royaume-Uni
- Angleterre, Grand Manchester, Midlands de l'Ouest
- Birmingham, Manchester
- Université de Manchester
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Le document en format XML
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Mccann</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Academic Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Academic Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust</wicri:regionArea><wicri:noRegion>Alder Hey Children's NHS Foundation Trust</wicri:noRegion></affiliation></author><author><name sortKey="Baildam, Eileen" sort="Baildam, Eileen" uniqKey="Baildam E" first="Eileen" last="Baildam">Eileen Baildam</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Academic Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Academic Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust</wicri:regionArea><wicri:noRegion>Alder Hey Children's NHS Foundation Trust</wicri:noRegion></affiliation></author><author><name sortKey="Beresford, Michael W" sort="Beresford, Michael W" uniqKey="Beresford M" first="Michael W" last="Beresford">Michael W. Beresford</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Academic Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Academic Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust</wicri:regionArea><wicri:noRegion>Alder Hey Children's NHS Foundation Trust</wicri:noRegion></affiliation></author><author><name sortKey="Davies, Rebecca" sort="Davies, Rebecca" uniqKey="Davies R" first="Rebecca" last="Davies">Rebecca Davies</name><affiliation wicri:level="4"><nlm:affiliation>Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester Academic Health Science Centre, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="De Cock, Diederik" sort="De Cock, Diederik" uniqKey="De Cock D" first="Diederik" last="De Cock">Diederik De Cock</name><affiliation wicri:level="4"><nlm:affiliation>Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester Academic Health Science Centre, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Foster, Helen E" sort="Foster, Helen E" uniqKey="Foster H" first="Helen E" last="Foster">Helen E. Foster</name><affiliation wicri:level="1"><nlm:affiliation>Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Southwood, Taunton R" sort="Southwood, Taunton R" uniqKey="Southwood T" first="Taunton R" last="Southwood">Taunton R. Southwood</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Child Health, University of Birmingham and Birmingham Children's Hospital, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Child Health, University of Birmingham and Birmingham Children's Hospital, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Thomson, Wendy" sort="Thomson, Wendy" uniqKey="Thomson W" first="Wendy" last="Thomson">Wendy Thomson</name><affiliation wicri:level="4"><nlm:affiliation>Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biologic, Medicine and Health, University of Manchester, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biologic, Medicine and Health, University of Manchester, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Hyrich, Kimme L" sort="Hyrich, Kimme L" uniqKey="Hyrich K" first="Kimme L" last="Hyrich">Kimme L. Hyrich</name><affiliation wicri:level="4"><nlm:affiliation>Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester Academic Health Science Centre, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author></analytic><series><title level="j">Rheumatology (Oxford, England)</title><idno type="eISSN">1462-0332</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Antirheumatic Agents (adverse effects)</term><term>Antirheumatic Agents (therapeutic use)</term><term>Arthritis, Juvenile (drug therapy)</term><term>Biological Products (adverse effects)</term><term>Biological Products (therapeutic use)</term><term>Child</term><term>Cohort Studies</term><term>Drug Administration Schedule</term><term>Drug Therapy, Combination</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Injection Site Reaction (etiology)</term><term>Male</term><term>Opportunistic Infections (chemically induced)</term><term>Registries</term><term>Rituximab (adverse effects)</term><term>Rituximab (therapeutic use)</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Antirhumatismaux (effets indésirables)</term><term>Antirhumatismaux (usage thérapeutique)</term><term>Arthrite juvénile (traitement médicamenteux)</term><term>Association de médicaments</term><term>Calendrier d'administration des médicaments</term><term>Enfant</term><term>Enregistrements</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Infections opportunistes ()</term><term>Mâle</term><term>Produits biologiques (effets indésirables)</term><term>Produits biologiques (usage thérapeutique)</term><term>Rituximab (effets indésirables)</term><term>Rituximab (usage thérapeutique)</term><term>Résultat thérapeutique</term><term>Études de cohortes</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antirheumatic Agents</term><term>Biological Products</term><term>Rituximab</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antirheumatic Agents</term><term>Biological Products</term><term>Rituximab</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Opportunistic Infections</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Juvenile</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antirhumatismaux</term><term>Produits biologiques</term><term>Rituximab</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Injection Site Reaction</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Arthrite juvénile</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antirhumatismaux</term><term>Produits biologiques</term><term>Rituximab</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Cohort Studies</term><term>Drug Administration Schedule</term><term>Drug Therapy, Combination</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Registries</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Association de médicaments</term><term>Calendrier d'administration des médicaments</term><term>Enfant</term><term>Enregistrements</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Infections opportunistes</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Études de cohortes</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rituximab (RTX) may be a treatment option for children and young people with JIA, although it is not licensed for this indication. The aim of this study was to describe RTX use and outcomes among children with JIA.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Manchester</li><li>Midlands de l'Ouest</li></region><settlement><li>Birmingham</li><li>Manchester</li></settlement><orgName><li>Université de Manchester</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kearsley Fleet, Lianne" sort="Kearsley Fleet, Lianne" uniqKey="Kearsley Fleet L" first="Lianne" last="Kearsley-Fleet">Lianne Kearsley-Fleet</name></region><name sortKey="Baildam, Eileen" sort="Baildam, Eileen" uniqKey="Baildam E" first="Eileen" last="Baildam">Eileen Baildam</name><name sortKey="Beresford, Michael W" sort="Beresford, Michael W" uniqKey="Beresford M" first="Michael W" last="Beresford">Michael W. Beresford</name><name sortKey="Davies, Rebecca" sort="Davies, Rebecca" uniqKey="Davies R" first="Rebecca" last="Davies">Rebecca Davies</name><name sortKey="De Cock, Diederik" sort="De Cock, Diederik" uniqKey="De Cock D" first="Diederik" last="De Cock">Diederik De Cock</name><name sortKey="Foster, Helen E" sort="Foster, Helen E" uniqKey="Foster H" first="Helen E" last="Foster">Helen E. Foster</name><name sortKey="Hyrich, Kimme L" sort="Hyrich, Kimme L" uniqKey="Hyrich K" first="Kimme L" last="Hyrich">Kimme L. Hyrich</name><name sortKey="Mccann, Liza J" sort="Mccann, Liza J" uniqKey="Mccann L" first="Liza J" last="Mccann">Liza J. Mccann</name><name sortKey="Sampath, Sunil" sort="Sampath, Sunil" uniqKey="Sampath S" first="Sunil" last="Sampath">Sunil Sampath</name><name sortKey="Southwood, Taunton R" sort="Southwood, Taunton R" uniqKey="Southwood T" first="Taunton R" last="Southwood">Taunton R. Southwood</name><name sortKey="Thomson, Wendy" sort="Thomson, Wendy" uniqKey="Thomson W" first="Wendy" last="Thomson">Wendy Thomson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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